POS1262 ULTRASONOGRPHIC EVALUATION OF SALIVARY GLANDS IN PATIENTS WITH SYSTEMIC SCLEROSIS

Background Although dry mouth is a common symptom in systemic sclerosis (SSc), there lack of studies evaluating the salivary glands this heterogenous disease. Objectives To study ultrasonographic changes patients with and to correlate these disease activity markers, clinical data autoantibodies. Methods Forty-seven SSc forty-three healthy age sex matched controls were studied. Duration illness, sicca symptoms, Schirmer’s test, joint internal organ evaluation including interstial lung disease, pulmonary artery hypertension, Raynaud’s phenomenon, digital pitting scars modified Rodnan total skin score. Laboratory investigations included acute phase reactants, antinuclear antibody, Anti-Ro-60/SSA, anti-La/SSB, anti-Topoisomerase 1 (anti–topo I) anticentromere (ACA). Salivary evaluated by ultrasound according most recent guidelines. Results The mean was 39.6±10.8 years duration 5.1±4.3 years. Sicca symptoms obvious among significant difference compared controls. pathological ≥2 seen 31 (66%) involved patients. anti-topo be significantly correlated Doppler signals (p=0.049) while ACA anti Ro not found any glandular pathology. Anti La (p=0.023). also, correlation anti-La submandibular gland score (p=0.03 0.045 respectively). Conclusion Ultrasonographic are quite frequent SSc. abnormalities correlating related autoantibodies especially topoisomerase antibodies. Figure 1. Gray scale power abnormailites patient diffuse sclersosis (A; parotid longitudenal scan withPD, B C; GS PD same patient.) REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.